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Henan Tongwei Medical Equipment Co., LtdCall us : +86 − −19139704654 // Email us : [email protected]
Henan Tongwei Medical Equipment Co., LtdCall us : +86 − −19139704654 // Email us : [email protected]
TW201039815A TW99109567A TW99109567A TW201039815A TW 201039815 A TW201039815 A TW 201039815A TW 99109567 A TW99109567 A TW 99109567A TW 99109567 A TW99109567 A TW 99109567A TW 201039815 A TW201039815 A TW 201039815A Authority TW Taiwan Prior art keywords compound 〇 group alkyl br Prior art date 2009-04-13 Application number TW99109567A Other
Hydrazine inhalation hepatotoxicity Kao YH(1) Chong CH Ng WT Lim D Author information: (1)Singapore Health Services 7 Hospital Drive Blk B #02-15 Singapore 169611 Singapore kaoyhyahoo Abstract Hydrazine is a hazardous chemical commonly used as a reactant in rocket and jet fuel cells
We elucidate the detailed effects of gut microbial depletion on the bile acid sub-metabolome of multiple body compartments (liver kidney heart and blood plasma) in rats We use a targeted ultra-performance liquid chromatography with time of flight mass-spectrometry assay to characterize the differential primary and secondary bile acid profiles in each tissue and show a major increase in the
Rat LC 50 inhalation 5300 mg/m 3 (4h) Rabbit LD 50 dermal 2000 mg/kg bw Rabbit skin irritation Mild irritant Rabbit eye irritation Mild irritant Skin sensitization Not sensitizing (Magnusson and Kligman) Short-term studies of toxicity Target/critical effect Body-weight gain decrement hepatotoxicity regenerative haemolytic
Lethargy was also observed (EHC 68 (1987) DFGOT Vol 1 (1992)) Moreover accidental inhalation exposure to vapors of this substance caused nausea vomiting local irritation of the upper respiratory tract and substantial increases in hepatotoxicity-related enzymes (DFGOT Vol 1 (1992) Initial Risk Assessment Report (NITE CERI NEDO 2005))
viii Skin Notation Profiles | Phenylhydrazine Glossary Absorption—The transport of a chemical from the outer surface of the skin into both the skin and systemic circulation (including penetration permeation and resorption) Acute exposure—Contact with a chemical that occurs once or for only a short period of time Cancer—Any one of a group of diseases that occurs when cells in the body
Practice Essentials Thousands of mushroom species are studied and collected by amateur mushroom hunters but only a handful cause death False morel mushrooms (eg Gyromitra esculenta Gyromitra ambigua Gyromitra infula) can cause fatal poisonings [1] These mushrooms are found on the ground or on rotten wood are orange-brown to brown have no gills and have convoluted brainlike caps that
Coriander (Coriandrum sativum L ) is a spice obtained from the plant belonging to the family Umbelliferae (Apiaceae) The green young coriander leaves also known as cilantro and the aromatic coriander fruit or seed find uses in curry meat dishes poultry and seafood dishes a variety of ethnic foods puddings breads soups and stews
We elucidate the detailed effects of gut microbial depletion on the bile acid sub-metabolome of multiple body compartments (liver kidney heart and blood plasma) in rats We use a targeted ultra-performance liquid chromatography with time of flight mass-spectrometry assay to characterize the differential primary and secondary bile acid profiles in each tissue and show a major increase in the
Hydrazine is highly toxic [9–15] and can cause neurotoxicity hepatotoxicity and nephrotoxicity in rodents [11] as well as liver kidney and central nervous system problems in humans [13 14] The United States Environmental Protection Agency (USEPA) has not classified hydrazine as a drinking water contaminant but as a probable human carcinogen (B2) [15]
Unsymmetrical dimethyl hydrazine( UDMH) is an important hydrazine fuels that are widely applied to carrier rocket and liquid missile As a chemical of corrosive poisonous irritant and adsorbent UDMH is harmful to staff The personnel exposed to UDMH suffered from aprosexia hypomnesia hepatitis etc along with increasing work duration Based on the review and analysis of the toxicity toxic
Hydrazine is an inorganic compound with the chemical formula N 2 H 4 It is a simple pnictogen hydride and is a colorless and flammable liquid with an ammonia-like odor Hydrazine is highly toxic and dangerously unstable unless handled in solution as e g hydrazine hydrate (NH2 NH 2 xH 2 O) As of 2015 the world hydrazine hydrate market amounted to $350 million
INHALATION: IMMEDIATELY leave the contaminated area take deep breaths of fresh air IMMEDIATELY call a physician and be prepared to transport the victim to a hospital even if no symptoms (such as wheezing coughing shortness of breath or burning in the mouth throat or chest) develop
30 08 2007Abstract Hydrazine is a hazardous chemical commonly used as a reactant in rocket and jet fuel cells Animal studies have demonstrated hepatic changes after hydrazine inhalation Human case reports of hydrazine inhalation hepatotoxicity are rare
Rat LC 50 inhalation 5300 mg/m 3 (4h) Rabbit LD 50 dermal 2000 mg/kg bw Rabbit skin irritation Mild irritant Rabbit eye irritation Mild irritant Skin sensitization Not sensitizing (Magnusson and Kligman) Short-term studies of toxicity Target/critical effect Body-weight gain decrement hepatotoxicity regenerative haemolytic
Using PBPK models the estimated amount of dichloromethane metabolized via the MFO pathway for mice exposed to 250 mg/kg bw per day in drinking water (highest dose group in Serota et al 1986b) or 2000 or 4000 ppm by inhalation (the two treatment groups for mice in NTP 1986) was relatively similar for all three groups whereas the amount of dichloromethane metabolized via the GST pathway was
ABSTRACT: A study on the effect of methanol extract of red beetroot (MEBV) against CCl 4 induced hepatotoxicity in male albino rats of Wistar strain (150 to 180g) was done Five groups with six rats each were used as positive control negative control and experimental with an oral dose of CCl 4 throughintra-peritoneal (IP) route and MEBV at 100gm/ml 200gm/ml 300gm/ml per os
Hydrazine / Hydrazine sulfate CASRN 302 - 01 - 2 Human health assessment information on a chemical substance is included in the IRIS database only after a comprehensive review of toxicity data as outlined in the IRIS assessment development process Sections I ( Health Hazard Assessments for Non Hydrazine inhalation hepatotoxicity PubMed
A causal association has been established between alcohol consumption and cancers of the oral cavity pharynx larynx oesophagus liver colon rectum and in women breast an association is suspected for cancers of the pancreas and lung Evidence suggests that the effect of alcohol is modulated by polymorphisms in genes encoding enzymes for ethanol metabolism (eg alcohol dehydrogenases
Becker RA Barrows LR and Shank RC 1981 Methylation of liver DNA guanine in hydrazine hepatotoxicity: dose-response and kinetic characteristics of 7-methylguanine and O6-methylguanine formation and persistence in rats Carcinogenesis 11:1181–1188 Biancifiori C Ribacchi R 1962
06 12 2017Mee lines nephropathy anemia and hepatotoxicity are systemic manifestations Autonomic dysfunction also may be a part of the which axonal transport was noted to be decreased by 30-50% in the rat optic nerve system immediately and 13 hours after inhalation exposure Hydrazine Hydralazine (s) Indomethacin Hyperinsulinemia
Hepatotoxicity led to its withdrawal but the subsequent discovery that it inhibited monoamine oxidase (MAO) led to the development of other hydrazine and non‐hydrazine MAO inhibitors which were advertised heavily in the early 1960s
Corneal damage may also occur It may cause corrosion Symptoms of exposure to this type of compound may include local irritation convulsions hepatotoxicity and hemolytic effects ACUTE/CHRONIC HAZARDS: This compound is highly toxic by inhalation ingestion and skin absorption It is corrosive to the skin eyes and mucous membranes
Inhalation REL (μg/m3) Oral REL (mg/kg Body Weight) Hazard Index Target Organs Human Data Ethylene oxide (75-21-8) 30 Nervous system Fluoride including Hydrogen Fluoride 13 F 14 HF 0 04 Bone and teeth respiratory system Glutaraldehyde (111-30-8)˜ 0 08 Respiratory system Hexane (n-) (110-54-3) 7000 Nervous system Hydrazine
9 1 2 Inhalation 9 1 3 Skin exposure 9 1 4 Eye contact 9 1 5 Parenteral exposure 9 1 6 Other 9 2 Chronic poisoning 9 2 1 Ingestion 9 2 2 Inhalation 9 2 3 Skin exposure 9 2 4 Eye contact 9 2 5 Parenteral exposure 9 2 6 Other 9 3 Course prognosis cause of death 9 4 Systematic description of clinical effects
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